A Haut-Doubs FVII variant depending on species-derived-thromboplastin reagent (F7:p.Arg337His)
نویسندگان
چکیده
منابع مشابه
The Use of a Stabilized Partial Thromboplastin Reagent in the Partial Thromboplastin Test.
1THE PARTIAL THROMBOPLASTIN TIME test was originally developed by Langdell et al. (1) as a method of following the therapy of hemophulic patients. These investigators found this test to be extremely sensitive to changes in Factor VIII brought about by whole blood or plasma transfusions. Extensive studies of the partial thromboplastin time test (PTT) by Rodman et il. (2) have shown that this tes...
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Activated partial thromboplastin time (APTT; also coagulation surface induced time [ID is a routine method for monitoring heparin treatment [2-5]. This time is influenced by the type of reagent, the method of analysis, and the laboratory instrument used; thus, the result will vary from one laboratory to another [6, 7]. Variation in heparin sensitivity between batches of re-agents produced from ...
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To contribute to the development of a reference reagent for monitoring heparin therapy, a lyophilized partial thromboplastin time (PTT) reagent was prepared from synthetic dioleoylphosphatidylcholine, dioleoylphosphatidylserine, and dioleoylphosphatidylethanolamine, with colloidal silica as activator. The reagent, coded 91/558, was contained in sealed glass ampoules; it deteriorated in a heat d...
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PCR product formation. During the dissociation protocol (slow cooling from 95 °C to 60 °C over a period of 20 min), the ABI 7700 instrument was also used in real time (every 3 s) to follow the melting profile of each sample. The correct melting peak for each sample was calculated by an appropriate algorithm as the first derivative at the flexus point (11 ). The flexibility of MTA allowed us to ...
متن کاملRecommendations for appropriate activated partial thromboplastin time reagent selection and utilization.
The activated partial thromboplastin time (aPTT) is widely used as a screening coagulation test and for monitoring unfractionated heparin therapy. Various commercial reagents are available, with different performance characteristics, particularly responsiveness to the lupus anticoagulant (LA). Because aPTT reagent selection significantly affects the interpretation of results, we reviewed Colleg...
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ژورنال
عنوان ژورنال: Haemophilia
سال: 2014
ISSN: 1351-8216
DOI: 10.1111/hae.12455